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However, important limitations exist in the current evidence: Most studies have been relatively small with short follow-up periods Many participants had concurrent obesity, making it difficult to separate weight loss effects from direct effects on binge eating behaviour Long-term efficacy and safety data specifically for binge eating disorder are lacking The psychological and behavioural components of BED may require interventions beyond pharmacological appetite suppression There is no official link established by regulatory bodies between GLP-1 agonists and binge eating disorder treatment

Tirzepatide can cause rapid fat mobilization, and the lipotropic agents in Lipo C, like choline and methionine, are thought to help the liver process this increased fatty acid load more efficiently, potentially reducing hepatic stress

309,315 Therapies targeting endothelial function are being explored to prevent or mitigate DPN progression (Fig