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Given that activation and differentiation of immune cells are coupled to metabolic reprogramming, regulating the metabolic activity of immune cells should be considered in the development of potential strategies that target glutamine metabolism 130,131

LOOH also participates in regulating oxidative stress-related signaling pathways, influencing apoptosis and antioxidant defense mechanisms [93], underscoring its critical role in cardiovascular diseases such as atherosclerosis and in neurodegenerative diseases, triggering tissue damage and pathological progression [93]

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J Biol Chem (2011) 286(30):2692130.10.1074/jbc.M110.195958 78 LiMBermakJCWangZWZhouQY

Redpath, M.E

The study indicated that although L