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In HBV-LC, macrophages are relatively less expanded and appear functionally distinct, with immune profiles more compatible with chronic virus-driven activation rather than the pronounced innate skewing observed in ALC (82)

This metabolic adaptation is critical because of the reduced entry of pyruvate into the TCA cycle by activated PDK1 and the increased lactate secretion in hypoxia 66

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A: When prescribed and administered by a healthcare professional, yes