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Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12

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Its extended half-life of approximately 2030 hours allows for less frequent dosing compared to standard IGF-1, with protocols typically running 46 weeks followed by an equal washout period to prevent receptor desensitization