[254][255][256][257] Unfortunately in spite of all the potentially beneficial effects of GLP-1 on glucose homeostasis, the therapeutic potential of naturally occurring GLP-1 is limited, due to its extremely short half-life of less than 2 minutes largely due to the degradation by the enzyme dipeptidyl peptidase IV (DPP-IV)
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He also highlights the importance of exercise, especially strength training, as GLP-1 users risk losing muscle mass along with fat
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Quick Answer: Weaning off Zepbound without gaining weight requires medical supervision, structured lifestyle modifications including increased physical activity (200-300 minutes weekly), high-protein and high-fiber dietary patterns, behavioral monitoring, and regular follow-up to address weight regain early
Meal composition matters enormously
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