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It takes time to reduce oxidative stress & pigment reduction internally

[Google Scholar] 74.Bogdanova A, Makhro A, Wang J, Lipp P, Kaestner L

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However, prolonged stress can overwhelm these processes, disrupting ER homeostasis and triggering apoptosis via the C/EBP homologous protein pathway [142]

(2015) combined both LC (0.4 mg/mouse) and ALC (0.12 mg/mouse) with micronutrients like zinc (4 ng/mouse), copper (0.8 ng/mouse) and iron (7 ng/mouse) and treated mice for 3 weeks daily to check the ovulation rate and oocyte quality