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As the mesocorticolimbic regions, which generally show increased dopamine, also show elevated levels of neuropathology and dysfunction during neuroHIV, the use of addictive or therapeutic substances could accelerate or exacerbate the progression of neuroHIV

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Mechanistically, its claimed effects track the biology of that TB4 motif: regulating actin dynamics, driving cell migration, and supporting new vessel growth and tissue repair

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