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GLP-1 has been shown to effectively contribute to the functional integration between the CNS and peripheral metabolism

The molecule is classified as a triple receptor agonist, which means it interacts with the glucagon like peptide 1 receptor (GLP 1R), glucose dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

In contrast, infusions of native GLP-1 at physiological doses (0.75 pmolkg 1 min 1 ) show a preferential effect on the visual perception of food, without significant alterations in palatability parameters (176)

Triglyceride levels decrease significantly, while LDL cholesterol reductions contribute to improved cardiovascular risk profiles