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The methionine cycle metabolites are further reduced compounding the effects of trisomy 21

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Supplementary Figure S5C )

Often referred to as the "master antioxidant," glutathione is a tripeptide composed of three amino acids: cysteine, glutamate, and glycine

Moreover, in both young and aged diabetic mice subjected to MCAO, exendin-4 treatment was shown to significantly polarize microglia/macrophages towards an anti-inflammatory M2 phenotype in the injured hemisphere compared to the non-injured hemisphere [76]

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