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The most common long-term side effects are GI-related, such as nausea, vomiting, diarrhea, constipation, and abdominal pain

Forgetting to refill a prescription in time can also lead to missed doses and an abrupt discontinuation of a drug

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It does mean this compound carries a documented adverse profile and an adverse regulatory position, and any laboratory handling it should treat it accordingly

TLRs can be localized either on the cell surface (TLR-1, -2, -4, -5, -6, -10) or in the endosome compartment (TLR-3, -7, -8, -9

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