McCoin CS, Knotts TA, Adams SH
Jul 1 2024 Chaopreecha et al., Phytomedicine, doi:10.1016/j.phymed.2024.156279 (date from preprint) Andrographolide attenuates SARS-CoV-2 infection via an up-regulation of glutamate-cysteine ligase catalytic subunit (GCLC) In vitro study showing andrographolide attenuates infection of SARS-CoV-2 wildtype and omicron variants in human lung epithelial cells and monkey kidney cells
The oral formulation requires specific administration on an empty stomach and may have variable absorption compared to injections
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The secreted proteins were purified from the harvested supernatants using a CaptureSelect Human Albumin Affinity Matrix (Thermo Fisher Scientific) packed in a 5-mL OPUS Chromatography Column (Repligen) 48
