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doi: 10.1136/BMJDRC-2016-000219 176 IfieERussellMADhayalSLeetePSebastianiGNigiLet al
Continuous isovolemic infusions of either saline or Ex9-39 were then started at a rate of 10 ml/hour by the use of a pump (Terufusion Infusion Pump, TE-171, Terumo), for Ex9-39 corresponding to a rate of 450 pmol kg body weight 1 min 1 , since this dose has previously been shown to block the insulinotropic effect of synthetic GLP-1 by ~90% (64)
When administered in vivo for 6 weeks to DHEA-induced PCOS rats, caffeic acid improved estrous cyclicity, lowered fasting blood glucose levels, enhanced liver function, and improved lipid profiles [157]
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