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The maintenance comparison has not been directly studied, but indirect evidence suggests that patients who switch from tirzepatide to semaglutide for maintenance may experience partial regain due to the loss of the GIP receptor component (Frias et al., NEJM 2021)

Some have reported more side effects while using compounded medications as well

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FDA (2026) Related Dosing Protocols Educational use only This guide is an educational research reference, not medical advice or a treatment plan