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Saxagliptin has been demonstrated to improve ED by upregulating stromal cell-derived factor 1 (SDF-1), which enhances EPC homing, and by activating phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling, thereby diminishing oxidative stress and apoptosis [160]

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2,3 Since then, multiple meta-analyses, using data collected from large-scale cardiovascular outcome trials and the U.S

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