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KDQOL-36 scale scores were significantly (p 0.02 indicated DIF)
In clinical trials investigating retatrutide, a dose-escalation approach has been used to minimise gastrointestinal side effects and improve tolerability
Dual agonism with GLP-1 and amylin As WL with GLP-1 RA and amylin analogues results both from distinct and overlapping pathways, a combination of these entero-pancreatic hormones may induce a synergistic WL effect [84]
This may also increase long-term health risks
The initial dose is 10 mcg once daily subcutaneously for 14 days, on the 15 th day the dose is increased to 20 mcg once daily subcutaneously
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