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10.1007/s00595-007-3706-2 52 ParkJ

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

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ROS-mediated DNA injury compromises satellite cell regenerative capacity, while oxidized macromolecules accumulate within atrophic fibers ( 5.1.2 Oxidative stress-induced structural and functional impairment of muscle fibers Oxidative stress (OS) is a critical mediator of structural and functional deterioration in skeletal muscle