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Mean 24-hour Plasma Glucose Profiles (standardized meals) in Patients with Type 2 Diabetes before (Baseline) and after 12 Weeks of Treatment with Semaglutide or Placebo Insulin Secretion Both first-and second-phase insulin secretion are increased in patients with type 2 diabetes treated with OZEMPIC compared with placebo

Considering the lack of robust cellular models for endogenous human GLP-1R, we developed a cell line with a GLP-1R density more comparable with endogenous tissue levels ( 30 )