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Discussion The present study reported that the use of a combination of nutraceutical compounds, specifically acetyl-L-carnitine, L-carnitine, L-ARG and NAC, was effective in reducing IR and in improving insulin sensitivity and HIE in obese PCOS patients

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they also suppress platelet activity, which may further contribute to cardiovascular protection ( 3.4 Complications and side effects of GLP-1 RAs Common side effects associated with GLP-1 receptor agonists (GLP-1 RAs) include gastrointestinal symptoms such as nausea (2560%), diarrhea, and vomiting (515%) ( While some studies have suggested a possible association between GLP-1 RAs and acute kidney injury (AKI), this has not been confirmed and appears to occur primarily in patients with underlying risk factors such as dehydration or severe gastrointestinal symptoms ( GLP-1 RA therapy should be discontinued under specific clinical conditions to minimize risk

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GLP-1s offer a promising new tool in addressing this challenge, which is why physicians, patients, and policymakers are all paying close attention

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