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[79] When used together with alpha-blockers, no benefit was reported in short-term trials, but in a longer-term study (34 years) there was a greater reduction in BPH progression to acute urinary retention and surgery than with either agent alone, especially in people with more severe symptoms and larger prostates

The authors are grateful for the financial support from the National Natural Science Foundation of China (81873312) and Jointly Guided Project of Heilongjiang Provincial Natural Science Foundation of China (JJ2022LH1048)

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