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When microdosing is combined with compounded sourcing, two uncertainties may overlap: Sub-therapeutic dosing without clinical validation Product variability outside manufacturer-controlled standards This does not automatically invalidate compounded medication

With this notion, the study of these molecular transducers has been approached by some authors in recent years from a top-down point of view, whereby sub-type specific, allosteric positive or negative modulators (PAM, NAMs), as well as direct agonists, are utilized as tools for pathway dissection and analysis (63, 64)