Effects of vegan diets on cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials
Vitamin B12 is a water-soluble vitamin essential for red blood cell formation, neurological function, and DNA synthesis Requirements vary by age: infants need 0.30.4 mcg daily, children 0.51.2 mcg, and lactating women 2.0 mcg Pernicious anaemia typically requires intramuscular injections of 1,000 mcg hydroxocobalamin, initially three times weekly then every 23 months Deficiency causes macrocytic anaemia and neurological symptoms including paraesthesia, balance problems, and cognitive changes that may become irreversible B12 is found almost exclusively in animal products
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The maintenance dose can be around 500-1000mg if the initial loading was successful, and can be adjusted based on frequency as well (500mg weekly or 1000mg every 2 weeks)
Le Roux8, A
Psychopharmacology 185:514523