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Patients with Hepatic Impairment In patients with moderate hepatic impairment (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100-mg dose of sitagliptin

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Rather, it is to engineer a pharmacologic signal in which glucagons catabolic properties are preserved while its hyperglycemic liability is buffered by incretin-mediated glucose control

Its 2025 and the media is in a panic over an alleged link between GLP-1 meds and blindness