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This dual action improves insulin response and may affect fat metabolism, which helps explain the stronger weightloss effect seen in trials, as outlined in this mechanism comparison of tirzepatide and semaglutide
Comparing Wegovy and Mounjaro Frequently asked questions Is Mounjaro better than Wegovy for weight loss
Zhou F, Tao H, Liu G, Zhang Y, Zhang Y, Zhou K
Butyrate directly induced intestinal gluconeogenesis via upregulating key enzymes G6PC and PCK1 with a cAMP-dependent mechanism, which can activate hypothalamic nuclei to decrease liver glucose production and regulate insulin sensitivity and glucose homeostasis (35)
Large portions overwhelm the slowed digestive system