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The latest FDA guidance focuses on the design of trials to demonstrate sustained weight reduction: "Weight reduction is defined herein as a long-term reduction in excess adiposity (body fat) with a goal of reduced morbidity and mortality

In SURMOUNT trials, tirzepatide 10 mg achieved average weight loss of 22% body weight, compared to 16% for semaglutide 2.4 mg in similar populations

Received: Accepted: Published: Issue date: DOI: Comments We note with interest the novel antibiotic identified by Ling and co-authors (Ling, L.L

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