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Semaglutides Mechanism Semaglutide (Ozempic, Wegovy) is a GLP-1 receptor agonist that works through gut hormone pathways: GLP-1 receptor activation: Mimics the natural gut hormone GLP-1, which is released after eating Acts on brain appetite centers to produce genuine hunger reduction Creates feelings of satiety and fullness that persist between meals Gastric effects: Slows gastric emptying, keeping food in the stomach longer Prolongs feelings of fullness after meals Reduces the volume of food needed to feel satisfied Metabolic effects: Improves insulin sensitivity Enhances glucose-dependent insulin secretion Reduces glucagon release What this means practically: Semaglutide makes you feel genuinely less hungry and more easily satisfied