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Additionally, pathway enrichment analysis further revealed that these alterations corresponded to disruptions in key metabolic routes, including the glucose-alanine cycle, glucose metabolism, beta-oxidation of very long-chain fatty acids, glutathione metabolism, transfer of acetyl groups into mitochondria, and the degradation pathways of branched-chain aminoacids (BCAA) (Figure S3)

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For instance, if infection severity increases, the system may escalate therapeutic payloads or adjust the release kinetics of nanocarriers to meet the heightened demand