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Long-term inhaled corticosteroids in preschool children at high risk for asthma

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doi: 10.3389/fmed.2023.1302352 51

Itaconate, derived from citrate produced in the TCA cycle, contains ,-unsaturated carboxylic acid, and covalently modifies at the Cys151 residue of Keap1 (78)

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In obese mice with diabetes, dapagliflozin reduces cardiac dysfunction interfering with activation of NLRP3 inflammasome and affects cardiac fibrosis by attenuating collagen 1 and collagen 3 deposition (Ye et al., 2017)