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IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance

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To ensure that those most in need receive treatment even if cost constraints limit broader access, coverage should be allocated based on criteria such as severity of obesity, comorbidities, and age

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