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In a 6-month study with a 6-month extension in adult subjects with type 1 diabetes, 99.8% of patients who received NOVOLOG were positive for anti-insulin antibodies (AIA) at least once during the study, including 97.2% that were positive at baseline

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The histopathological changes were reflected in the biochemical measurements, as TAA injection induced marked elevation in the plasma levels of aminotransferases (ALP, AST, and ALT) as well as GGT, all of which are indicative of hepatocellular damage