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A case in point is metformin, a commonly used drug to treat type 2 diabetes mellitus

Uehara et al., 1995

In the nineties, Sikiric licensed the compound to a Croatian company called Pliva, which sought a treatment for ulcerative colitis

Only 57% of participants reached the highest 2.4mg/2.4mg dose

This leads to the accumulation of glucose and other intermediate metabolites of this pathway and is shifted to other alternative pathways of glucose metabolism, together with increased production of end products of enhanced glycosylation

10.1016/j.clnesp.2022.01.038 Clin