Structure of bacterial glutathione-S-transferase maleyl pyruvate isomerase and implications for mechanism of isomerisation
10.3390/ph17010038 294 ZhangS.-J.LuoD.LiL.TanR.-R.XuQ.-Q.QinJ.et al (2017a)
Mechanism of Action Acetyl Group Protection : The attached acetyl group acts as a molecular shield, preventing digestive enzymes from breaking down glutathione prematurely in the stomach and intestines, which allows the intact molecule to reach target tissues like the liver, lungs, and brain
Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum
SLC25A39 as well as mitochondrial GSH may also represent promising drug targets for cancer, since manipulating SLC25A39 functioning or mitochondrial GSH in tumor cells may induce selective oxidative stress, leading to cell death
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