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Probiotics as Lactocaseibacillus rhamnosus zz-1 can enhance tight junction protein expression (including ZO-1, occludin, and claudin-1) and promote epithelial barrier repair, thus limiting antigenic load and reducing systemic inflammation (Xu et al., 2023)

Semaglutide works by mimicking GLP-1, a naturally occurring hormone that triggers cell receptors in the digestive system and brain

To minimize confounders, the groups were matched based on numerous demographic and chronic disease variables

Combined treatments produce distinct MMP activation profiles, suggesting complementary extracellular matrix remodelling mechanisms quantifiable through gelatin substrate degradation assays

This can be attributed to the replenishment of key nutrients that aid in tissue repair and reduce inflammation, such as vitamin C and zinc

This finding initially led to exendin-4 (Ex4) (exenatide) (32), a human GLP-1 receptor agonist