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The Intestine as a Primary Reward Sensor A major conceptual shift is recognizing the gastrointestinal tract functions as a sensory organ for reward

High-fat, fried, and very rich foods are the most common triggers for nausea and gastrointestinal discomfort on GLP-1 medications because they slow gastric emptying further on top of the medication's effect

1,5 Healthy fats Monounsaturated and polyunsaturated fatty acids (MUFAs and PUFAs, respectively) enhance GLP-1 secretion through free fatty acid receptor and G-protein-coupled receptor signaling pathways, including GPR40, GPR119, and FFAR1/3

At negative 20 degrees Celsius or colder, lyophilized retatrutide remains stable for up to 48 months

The drugs may act on blood vessels or on fluid balance in ways no one has pinned down