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In rats, the drugs, known as glucagon-like-peptide-1 (GLP-1) receptor agonists, have been shown to cause thyroid C-cell tumors

Response: We thank commenters for their feedback regarding the feasibility of the measure and confidence in its evidence-based specifications

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New medications entering clinical trials and approaching approval include triple agonists like retatrutide , combination therapies like CagriSema , oral formulations that eliminate the need for injections, and even transdermal GLP-1 patches

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Notably, weight loss did not differ significantly between groups, so it does not explain the observed effect