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Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans

Such enzymatic inhibition thus blocks the synthesis of glutathione

Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells

Its antioxidants protect liver cells

In liver injury models, GSH depletion predicts hepatotoxicity, whereas restoration reduces necrosis and supports cellular recovery

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