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SAG uses a thioester (S-acyl) bond, which is cleaved specifically by cytoplasmic thioesterases, offering a more targeted intracellular release mechanism with a cleaner safety profile demonstrated in human dosing studies

doi: 10.1089/aid.2016.0303 35 VenketaramanV.DayaramY

However, the researchers only observed this increase in younger adults

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