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Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

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PRPP is a crucial intermediate in multiple cellular metabolic pathways, including the synthesis of purine and pyrimidine nucleotides, histidine, tryptophan, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) 7 (Fig