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In a head-to-head trial, participants using Zepbound achieved an average weight loss of approximately 20.2% over 72 weeks, while those on Wegovy experienced about a 13.7% reduction

This allows for the influx of external Ca 2+ , ultimately stimulating light emission through the activity of the Ca 2+ sensitive photoprotein

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It was approved in 2019 for diabetes management

The dosing structures are fundamentally different because each peptide has a different receptor profile, different potency per milligram, and different pharmacokinetic properties

Both the number and type of poison control calls changed significantly after approval, reflecting the rapid expansion of semaglutide use beyond people with diabetes to a much larger population seeking weight loss