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It has a favorable topical tolerability signal in cosmetics and preclinical models, but there is no published human trial quantifying its side effects, and no systemic/injectable safety data at all

Co-eluting, high abundant interferences in TOFMS survey scans resulted in missed MS/MS acquisition of target peptides

Inflammation also shifts tryptophan metabolism away from serotonin to neurotoxic kynurenine pathway metabolites, like quinolinic acid, and disturbs neurotransmission and thus plays a role in depressive symptoms (Chen et al., 2021

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Evidence suggests that KP dysregulation may contribute to MDD by disrupting the balance between excitatory and inhibitory neurotransmission

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