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It was proposed that this increase would promote the occurrence of oxidative damage during the aging process [97] and that perhaps lipid peroxide induced membrane damage could be crucial to the onset of geriatric disease

Clinical and preclinical studies support these antioxidant effects

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At the tissue level, IFN-stimulated genes are overexpressed only in infiltrated islets of recent-onset T1D patients 7 , in line with an enhanced pancreatic IFN- expression 8