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Although direct evidence of BCAA-mediated activation of these pathways is lacking, mitochondrial dysfunction, ROS production, and metabolic intermediate accumulation resulting from BCAA metabolic dysregulation can all function as damage-associated molecular patterns (DAMPs) to activate inflammatory pathways

Nutrients 11 (2019)

It may cause gastrointestinal symptoms, such as gas, bloating, diarrhea, and abdominal discomfort, especially when consumed in large doses

Senescent cells survive by sequestering p53 through FOXO4 interaction

Results Finally, 45 cases in L-carnitine group versus 47 cases in the placebo group were completed study per protocol