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Glutamate works not only as a point-to-point transmitter, but also through spill-over synaptic crosstalk between synapses in which summation of glutamate released from a neighboring synapse creates extrasynaptic signaling/volume transmission
LC also enhances cell viability via the release of cellular enzymes and oxygen consumption [15]
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Josso N, Briard ML
Instead, it seems likely that the DMSA's effect was due to the reduction of toxic metals in the RBC, allowing glutathione to return to a normal level
Therefore, large randomized controlled studies are needed to establish the efficacy in addition to a careful phenotypic characterization of cerebellar disorders, given their high heterogeneity
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