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CKD affects the bioavailability and pharmacokinetics of direct oral anticoagulants since they are all, at least partially, excreted by the kidneys (the renal clearance of dabigatran is around 80%, of edoxaban 50%, of rivaroxaban 33%, and of apixaban 27%) and may require dose adjustments in patients with reduced eGFR

The medication is working your appetite is down, the scale is moving

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