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study showed no significant elevation of cortisol or prolactin even at doses 200 times the effective GH-releasing dose (4)

Inject at bedtime

However, people vary a lot in what they need and the best thing to do is make a diary of your symptoms and follow those to determine the frequency with which you need injections

But individuals starting semaglutide who are also dealing with GI side effects, reduced food and fluid intake, and the physiological stress of early dose escalation may notice this elevated baseline more acutely than someone in a controlled trial environment