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Metformin: activation of 5 AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action

Correspondence Address : Devinder M Thappa Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry - 605 006 India Introduction The human skin color is one of the most perceptible phenotypic variations among humans and is determined primarily by the type and amount of melanin synthesized within melanosomes and the pattern of melanosome distribution within the melanocytes

Equally important are behavioral measures: drinking at least 23 liters of water daily, avoiding alcohol and high-purine foods (organ meats, shellfish, certain fish), and maintaining consistent medication adherence

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Long-Term Side Effects and Considerations Most discussion focuses on initial side effects, but long-term considerations matter for ongoing treatment

At a certain age, the over-the-counter retinoids might be a better, gentler option, she said