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In adults with obesity and knee osteoarthritis, retatrutide delivered: 9mg dose: 26.4% body weight reduction at 68 weeks 12mg dose: 28.7% body weight reduction at 68 weeks (average of 71.2 pounds lost) Placebo: 2.1% body weight reduction The 68-week timeframe is longer than the Phase 2 trial, which partially explains the higher numbers

Several resting-state fMRI studies have reported altered functional connectivity in brain regions involved in cognitive control and emotional processing, including the prefrontal cortex, hippocampal and parahippocampal regions, and the cingulate cortex, in patients with ME/CFS

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10.1093/bja/86.1.110 134 KezicA.SpasojevicI.LezaicV.BajceticM

If you have any risk factors for any of the conditions these drugs can prevent, Im going to do everything I can to get you on these medications, because to me, it would be inappropriate not to