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Gildeeva GN, Yurkov VI

Some of the most frequent conditions linked with carpal tunnel syndrome include thyroid dysfunction, diabetes, high blood pressure, fractures, trauma to the wrist, autoimmune disorders such as rheumatoid arthritis, or fluid retention from menopause and pregnancy

This finding aligns with the notion proposed by Rose EC et al

Notably, adding a mGluR2/3 antagonist was suggested to inhibit the action of spadin, pointing towards a dependency of spadin on mPFC TREK-1 channels that are possibly linked to mGluR2/3 receptors

In contrast, GLP-1 RA use was associated with a significantly lower risk of pemphigus compared with insulin (HR 0.33, 95% CI 0.150.74), with no significant differences versus other oral agents ( Figure 3B )