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Description

If left uncontrolled over the long term, it can lead to multisystem complications

the main SURMOUNT-1 trial [2] does not report body composition

TRIUMPH-Outcomes is not required for the initial obesity indication and isn't expected to report until 20282029

However, it can also be the result of low B6, low folate, renal failure, or hypothyroidism

That is especially true if the deeper goal is not just a lower weight, but better metabolic health, better energy, lower cardiovascular risk, and better long-term function

Hormonal effects related to IGF-1 and androgen sensitivity may play a role