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Exploratory and hypothesis-generating metabolomics approaches suggest a trend toward a deeper alteration of the antioxidant system in severe IPTB, and NACs role in H 2 S and NO metabolism

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There is a need to consider each dimension to provide a more comprehensive evidence base for prioritising action

The presence of inflammatory mediators can induce further activation of microglia and astrocytes, which in turn release additional inflammatory factors, leading to even greater neuronal damage

2015;7:a021683

Enhanced oxidative stress and platelet activation in patients with Cushing's syndrome