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In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

234 BM-MSCs overexpressing HO-1 could improve the survival rate and attenuate lung impairment in ALI rats by inhibiting apoptosis and enhancing the paracrine effects of MSCs

Dietary tablet supplements of vitamin B12 and fortified foods are usually in the form of cyanocobalamin because it is a more cost-effective form of B12

Capella-Gutirrez S, Silla-Martnez JM, Gabaldn T

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This makes the improvements seen with paraxanthine particularly noteworthy, as they suggest potential applications for age-related cognitive decline